Merging domino and redox chemistry: stereoselective access to di- and trisubstituted β,γ-unsaturated acids and esters.

نویسندگان

  • David Tejedor
  • Gabriela Méndez-Abt
  • Leandro Cotos
  • Fernando García-Tellado
چکیده

Merging is the game! The coupling of a domino reaction and an internal neutral redox reaction constitutes an excellent manifold for the stereoselective synthesis of di- and trisubstituted olefins featuring a malonate unit, an ester, or a free carboxylic acid as substituents at the allylic position (see scheme; MW=microwave). The reaction utilizes simple starting materials (propargyl vinyl ethers), methanol or water as solvents, and a very simple and bench-friendly protocol.

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عنوان ژورنال:
  • Chemistry

دوره 18 12  شماره 

صفحات  -

تاریخ انتشار 2012